DAY 1, MONDAY, MARCH 27
09:00-10:45 Arrival & Registration (Powerhouse Museum – Target Theatre Foyer)
10:45-11:00 Welcome by organisers and housekeeping: Tony Cesare
Session I: DNA Repair
Session Chair: Kum Kum Khanna (Queensland Institute for Medical Research, QLD)
11:00-11:25 Eloise Dray (TRI, Queensland University of Technology, QLD)
“DNA repair proteins in breast cancer: both the problem and the solution”
11:25-11:40 Brian Gabrielli (Mater Research Institute, QLD)
“The common ATM Ser49Cys variant is functionally defective for DNA damage response signalling”
11:40-11:55 Georgia Kafer (Kyoto University, Kyoto, Japan)
“Investigating cytosine hydroxymethylation during DNA repair”
11:55-12:10 Sylvie van Twest (St Vincent’s Institute of Medical Research, VIC)
“Biochemical reconstitution of the ubiquitin ligase defective in Fanconi Anaemia”
12:10-12:35 Tamás Fischer (John Curtin School of Medical Research, Canberra) “RNA-DNA hybrids and RNase H activity are required for efficient DSB repair”
12:35-14:15 Lunch and Posters (Target Theatre Foyer)
Session II: Cell Division I
Session Chair: Brian Gabrielli (Mater Research Institute, QLD)
14:15-14:40 Janni Petersen (Flinders University, SA)
“Environmental control of cell growth and division”
14:40-14:55 Qian Du (Garvan Institute of Medical Research, NSW)
“DNA replication timing shapes the cancer epigenome”
14:55-15:10 Noa Lamm-Shalem (Children’s Medical Research Institute, NSW)
“An actin-dependent mechanism facilitates nuclear-cytoplasmic cross-talk to guard genome stability”
15:10-15:35 Damien Hudson (Murdoch Children’s Research Institute, VIC)
“RMI2-a new disease gene causing Bloom (like) syndrome”
Poster Fast-Forward
Session Chair: Harriet Gee (Department of Radiation Oncology, Westmead Hospital, NSW)
15:35 – 15:37 Sam Rogers (Garvan Institute of Medical Research, NSW)
“SnapShot: Phosphoregulation of mitosis”
15:37 – 15:39 Heather Murray (Hunter Medical Research Institute, NSW)
“Synergistic targeting of DNA-PK in acute myeloid leukaemia (AML)”
15:41 – 15:43 Susanne Heinzel (Walter and Eliza Hall Institute, VIC)
“Myc as a regulator of T and B cell responses”
15:43 – 15:45 Jirawas Sornkum (Peter MacCallum Cancer Centre, VIC)
“Dual targeting of ribosomal gene chromatin and transcription as a novel therapeutic strategy for synergistic activation of cell cycle checkpoints in acute myeloid leukaemia”
15:45 – 15:48 Sarah Alexandrou (Garvan Institute of Medical Research, NSW)
“CDK inhibition in combination with endocrine therapy to prevent the emergence of resistance in breast cancer”
15:48-16:15 Coffee/Tea
16:15-17:00 ACCM PLENARY KEYNOTE LECTURE: DANIEL DUROCHER
The Lunenfeld-Tanenbaum Research Institute, Canada
“Charting the response to DNA damage”
Chair: Andrew Deans (St Vincent’s Institute of Medical Research, VIC)
17:00-18:55 Poster session with cheese & wine (Target Theatre Foyer)
“All presenters to stand by posters”
19:00 Welcome Dinner and Drinks (Free to all registrants)
Transport Exhibition Room, Powerhouse Museum
DAY 2, TUESDAY, MARCH 28
Session III: Telomeres
Session Chair: Roger Reddel (Children’s Medical Research Institute, NSW)
09:00-09:15 Rebecca Dagg (Children’s Medical Research Institute, NSW)
“Extensive proliferation of human cancer cells with ever-shorter telomeres”
09:15-09:30 Barbara Hübner (Nanyang Technological University, Singapore)
“Correlative microscopy of telomeres”
09:30-10:00 Tracy Bryan (Children’s Medical Research Institute, NSW)
“Links between DNA replication, DNA damage responses and telomerase extension of telomeres”
10:00-10:40 THE GEORGINA SWEET AWARD FOR WOMEN IN BIOMEDICAL SCIENCE
KEYNOTE Lecture: JULIE COOPER
National Cancer Institute, USA
“Revelations from the edge of the nucleus: telomeric control of kinetochore assembly, nuclear envelope breakdown and chromosome detanglement”
Chair: Tony Cesare (Children’s Medical Research Institute, NSW)
10:40-11:05 Coffee/tea
Session IV: Informatics
Session Chair: Graham Mann (Westmead Institute of Medical Research, NSW)
11:05-11:30 Nic Waddell (Queensland Institute of Medical Research, QLD)
“Mutational processes and potential clinical utility in cancer”
11:30-11:55 Tiannan Guo (Children’s Medical Research Institute, NSW)
“Measuring a subset of proteins involved in cell cycle and DNA damage response in hundreds of cancer cells and tumor tissues using PCT-SWATH mass spectrometry”
11:55-12:10 Michael Lee (Children’s Medical Research Institute, NSW)
“Development of a whole genome sequencing based classifier to determine telomere maintenance mechanism in tumours”
12:10-12:35 Juliet French (Queensland Institute of Medical Research, QLD)
“Long noncoding RNAs, CUPID1 and CUPID2, mediate breast cancer risk at 11q13 by modulating response to DNA damage”
12:35-14:00 Lunch and Posters (Target Theatre Foyer)
Proudly sponsored by the Sydney West Radiation Oncology Network
Session V: Cell Proliferation and control
Session Chair: Antony Braithwaite (University of Otago, New Zealand)
14:00-14:25: Marco Herold (Walter and Eliza Hall Institute, VIC)
“Using CRISPR/Cas9 technology to identify and validate novel cell death regulators for cancer therapy”
14:25-14:40 Naisana Asli (University of Sydney, NSW)
“Cell cycle quiescence, epithelial plasticity and chemo-resistance intersect through BMP pathway activity in human epithelial ovarian carcinoma”
14:40-14:55 Wayne Crismani (St Vincent’s Institute of Medical Research, VIC)
“FANCM and associated proteins limit meiotic crossovers”
14:55-15:20 Carl Walkley (St. Vincent’s Institute of Medical Research, VIC)
“Understanding the role of Recql4 in normal and malignant disease: Insights from blood and bone development”
15:20-15:45 Coffee/Tea
Session VI: Structural and Single Molecule Science
Session Chair: Katharina Gaus (University of New South Wales, NSW)
15:45-16:10 Nick Dixon (University of Wollongong, NSW)
“Design principles of a dynamic molecular machine: the bacterial replisome”
16:10-16:25 Roland Gamsjaeger (Western Sydney University, NSW)
“A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution”
16:25-16:50 Elizabeth Hinde (University of New South Wales, NSW)
“Imaging chromatin dynamics during the DNA damage response”
16:50-17:05 Coffee/Tea
17:05-17:50 THE NSW GOVERNMENT “MAKE IT HAPPEN”
KEYNOTE Lecture: ANTOINE VAN OIJEN
University of Wollongong, NSW
“Single-molecule imaging of DNA replication and repair”
Chair: Hilda Pickett
17:50-18:45 Drinks, Poster viewing
18:45 – 19:00 Free Bus Transport to the Opera House for the Conference Dinner
Proudly Sponsored by Brightside scientific
19:15 – 10:30 Conference Dinner, Opera Bar – Circular Quay
DAY 3, WEDNESDAY, MARCH 29
Session VII: Cell Division II
Session Chair: Leonie Quinn (John Curtin School of Medicine, ANU, ACT)
09:00-09:15 Don Cameron (John Curtin School of Medical Research, ACT)
“RNA polymerase I transcription inhibitor CX-5461 functions as a targeted DNA damaging agent to selectively kill tumour cells”
09:15-09:30 Radoslaw Szymd (Agency for Science, Technology and Research, Singapore)
“Cdk1 activity guards S phase integrity”
09:30-10:00 Patrick Humbert (Latrobe University, VIC)
“Erythroid Enucleation: An unusual cell division?”
10:00-10:40 The Company of Biologists KEYNOTE Lecture: MARCOS MALUMBRES
National Cancer Research Centre, Spain
“Balancing the activity of kinases and phosphatases in the cell cycle and beyond”
Chair: Andrew Burgess (Garvan Institute of Medical Research, NSW)
10:40-11:10 Coffee/tea
Proudly sponsored by Genesis Cancer Care
Session VIII: Clinical Implications
Session Chair: Helen Rizos (Macquarie University, NSW)
11:10-11:35 Steve Lane (Queensland Institute of Medical Research, QLD)
“The preclinical efficacy of targeting telomerase in human acute myeloid leukaemia (AML)”
11:35-11:50 Tara Roberts (Ingham Institute for Applied Medical Research, NSW)
“ATM loss leads to accumulation of unrepaired DNA damage and cytosolic DNA which induces inflammation and neurodegeneration”
11:50-12:05 Jordan Hastings (Garvan Institute of Medical Research, NSW)
“Predicting chemoresistance in lung adenocarcinoma by modelling drug induced signalling dynamics”
12:05-12:20 Ana Esteves (Chris O’Brien Lifehouse, NSW)
“The relative importance of cell cycle and bystander effects in radiation sensitivity”
12:20-12:45 David Thomas (Garvan Institute of Medical Research, NSW)
“The Molecular Screening and Therapeutics (MoST) Study: a framework for signal- seeking basket trials for rare and neglected cancers”
12:45-12:55 Closing remarks + Prizes (Liz Caldon)
12:55 Lunch & Departure
Australian Cell Cycle, DNA repair and Telomere Meeting 